Effect of Co-administration Rotenone and Crocin on Biochemical and Histopathological Changes in Rat᾽s Kidney

Background: Rotenone is one of the most widely used pesticides in agriculture and may affect public health through food chain. A possible mechanism rotenone toxicity oxidative stress. This study, supportive effect crocin (a substance derived from saffron) as an antioxidant on renal experimental animal model was investigated. Methods: First, male rats were divided into 4 groups (6 each group) received saline, crocin, rotenone-crocin combination intraperitoneally for 10 days, respectively. Blood kidney tissue samples then isolated biochemical factors including creatinine, nitrogen blood urea (BUN), sodium, potassium, Malondialdehyde catalase measured. The kidneys examined histopathologically with a light microscope. Results: results showed that caused damage to tissue, which observed form vacuole degeneration, hyperemia influx inflammatory cells. Crocin has also been shown reduce severity rotenone-induced damage. Also changes not statistically significant between groups. Conclusions: protective influence histopathological rat᾽s following administration.